Endocrine system organoids: from experimental models to clinical perspectives for hormonal disorders

Abstract

Introduction: In this narrative review on organoids from endocrine glands and tissues, we discuss the history of these cell culture models and the clinical perspectives that organoids offer for different endocrine disorders. Objective: This work aims to describe the evolution of the use of organoids from endocrine tissues, as well as the clinical perspectives that these models offer through pathophysiological monitoring and specific pharmacological tests applied to the organoid cultivated from individual samples. Methodology: The research was done through a bibliographic search in the PubMed, SciELO and Google Scholar databases from keywords registered in DeCS/MeSH. Result and conclusion: Understanding the development of normal and tumor tissues can favor tissue engineering and the development of drugs for specific treatment of a given disease and regenerative medicine. Although there are some limitations and restrictions of organoids in animal models, there is no doubt that long-term three-dimensional culture can provide opportunities to develop mechanisms of resolution of several endocrinological pathologies.